Epigenomics of Patient Outcomes after Subarachnoid Hemorrhage

Last modified: 
09/03/2018 - 08:15

Epigenomics of Patient Outcomes after Subarachnoid Hemorrhage

Project Data

Contact Information
Main Point of Contact:
First Name: 
Yvette
Last Name: 
Conley
Credentials: 
PhD, FAAN
Institutional Affiliation: 
University of Pittsburgh
Email: 
yconley@pitt.edu
Study Information
Origin of Samples/Data: 
Human samples and/or data
Study Description: 
The aims of this project focus on the daily genome-wide methylomic changes that occur in DNA representing the CNS (DNA extracted from the cerebral spinal fluid (CSF) drained as standard of care) for the first 14 days after aSAH using state of the science, high-throughput, genomic based methodologies; determining if this methylomic data impacts delayed cerebral ischemia (DCI) as well as patient outcomes after aSAH.
Additional Information
Grant Number (if applicable): 
R01NR013610
Grant Source: 
NIH/NINR
Data Information
Omic Data Available: 
Yes
Please Specify Epigenomic: 
DNA methylation
Epigenomic Platform(s): 
Illumina Infinium 450K
Clinical and/or other data available?: 
Yes
Demographic information: 
age, sex, race
Phenotype(s): 
delayed cerebral ischemia; acute clinical deterioration; 3, 6, 12, and 24 month MRS and GOS outcomes
Data on additional variables: 
initial extent of injury/bleed (Fisher and Hunt & Hess scores)
Additional Information: 
Daily CSF samples (from EVD bags); DNA extracted from daily CSF samples; plasma from day closest to rupture available; DNA extracted from blood
Sample Information
Samples available for prospective analysis: 
Yes
Whole Blood: 
No
Saliva: 
No
Serum: 
No
Other Tissue: 
Yes
Specify Other Tissue: 
CSF; plasma
Extracted DNA: 
Yes
Extracted RNA: 
No
Other Extracted Biological Material: 
No
Approximate Number of Samples: 
580
Additional Information: 
Daily CSF samples (from EVD bags); DNA extracted from daily CSF samples; plasma from day closest to rupture available; DNA extracted from blood