Epigenomics of Patient Outcomes after Traumatic Brain Injury

Last modified: 
09/03/2018 - 08:28

Epigenomics of Patient Outcomes after Traumatic Brain Injury

Project Data

Contact Information
Main Point of Contact:
First Name: 
Yvette
Last Name: 
Conley
Credentials: 
PhD, FAAN
Institutional Affiliation: 
University of Pittsburgh
Email: 
yconley@pitt.edu
Study Information
Origin of Samples/Data: 
Human samples and/or data
Study Description: 
The aims of this project focus on the daily genome-wide methylomic changes that occur in DNA representing the CNS (DNA extracted from the cerebral spinal fluid (CSF) drained as standard of care) for the first 5 days after TBI using state of the science, high-throughput, genomic based methodologies; determining if this methylomic data impacts acute or long term patient outcomes after TBI.
Additional Information
Grant Number (if applicable): 
R21NR015142
Grant Source: 
NIH/NINR
Data Information
Omic Data Available: 
Yes
Genotype Platform(s): 
Illumina Human Core Exome
Please Specify Epigenomic: 
DNA methylation
Epigenomic Platform(s): 
Illumina Infinium 450K
Clinical and/or other data available?: 
Yes
Demographic information: 
age, sex, race
Phenotype(s): 
3, 6, 12, and 24 month patient outcomes such as GOS, DRS, NRS, Rivermead symptom inventory; intracranial pressure; acute surgeries
Additional Information: 
Daily CSF samples for first 5 days after injury; daily blood samples for first 5 days after injury; daily samples linked to daily in-hospital data and longer term outcomes
Sample Information
Samples available for prospective analysis: 
Yes
Whole Blood: 
No
Saliva: 
No
Serum: 
No
Other Tissue: 
No
Extracted DNA: 
Yes
Extracted RNA: 
No
Other Extracted Biological Material: 
Yes
Specify Other Extracted: 
daily CSF, daily plasma
Approximate Number of Samples: 
600
Additional Information: 
Daily CSF samples for first 5 days after injury; daily blood samples for first 5 days after injury; daily samples linked to daily in-hospital data and longer term outcomes