Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure- InterGEN

Last modified: 
09/07/2018 - 15:47

Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure- InterGEN

Project Data

Contact Information
Main Point of Contact:
First Name: 
Jacquelyn
Last Name: 
Taylor
Credentials: 
PhD, PNP-BC, RN, FAHA, FAAN
Institutional Affiliation: 
New York University
Email: 
jackie.taylor@nyu.edu
Alternative Point of Contact:
First Name: 
Laura
Last name: 
Prescott
Credentials: 
MS
Institutional Affiliation: 
Project Manager
Email: 
Study Information
Origin of Samples/Data: 
Human samples and/or data
Study Description: 
Our goal is to better understand the effects of psychological, environmental, genetic, epigenetic, and ancestry factors on blood pressure in Black/African American women and their young children. We have genomic (EWAS and GWAS), psychological (perceived racism/discrimination, parenting stress, symtpoms of depression, etc) and clinical data (blood pressure, BMI, % body fat and % body water) collected at 4 times points every 6 months for 2 years on 250 African American mother-child dyads.
Additional Information
Grant Number (if applicable): 
R01NR013520
Grant Source: 
NINR
Data Information
Omic Data Available: 
Yes
Genotype Platform(s): 
Illumina MEG Array
Please Specify Epigenomic: 
EPIC 850K Array
Epigenomic Platform(s): 
Illumina
Please Specify Other Omics: 
Whole Exome Sequencing and Whole Genome Sequencing
Other Omics Platform(s): 
Illumina
Clinical and/or other data available?: 
Yes
Demographic information: 
SES, birth history, age, gender, number of children, health history, zip code, medical history, fam medical history, medications, comorbid conditions
Phenotype(s): 
blood pressure (hypertension), body mass index, % body fat, % body water (obesity)
Data on additional variables: 
medications, stress, parenting stress, trauma, coping, perceived racism/discrimination, attitudes toward genetic testing, acculturation, substance use and abuse
Additional Information: 
GWAS, EWAS and ancestry informative markers on N=500 Whole Genome Sequencing on N=100 samples Exome Sequencing on N=286 samples
Sample Information
Samples available for prospective analysis: 
No
Whole Blood: 
No
Saliva: 
Yes
Serum: 
No
Other Tissue: 
No
Extracted DNA: 
Yes
Extracted RNA: 
No
Other Extracted Biological Material: 
No
Approximate Number of Samples: 
500