Whole Genome Sequencing as a Screening Tool for Cardiovascular Diseases among African Americans in the Community

Last modified: 
09/07/2018 - 15:45

Whole Genome Sequencing as a Screening Tool for Cardiovascular Diseases among African Americans in the Community

Project Data

Contact Information
Main Point of Contact:
First Name: 
Jacquelyn
Last Name: 
Taylor
Credentials: 
PhD, PNP-BC, RN, FAHA, FAAN
Institutional Affiliation: 
New York University
Email: 
jackie.taylor@nyu.edu
Alternative Point of Contact:
First Name: 
Laura
Last name: 
Prescott
Credentials: 
MS
Institutional Affiliation: 
New York University
Email: 
Study Information
Origin of Samples/Data: 
Human samples and/or data
Study Description: 
This project attempts to address the lack of inclusion and subsequent lack of knowledge about common and potentially pathogenic or likely pathogenic variants among African American populations and aims to provide recommendations for whole genome sequencing as a screening tool in community and clinical settings for use in early detection and treatment of cardiovascular related diseases that may help to reduce these health disparities.
Additional Information
Grant Number (if applicable): 
PECASE-R01NR013520
Grant Source: 
NINR
Data Information
Omic Data Available: 
Yes
Genotype Platform(s): 
Illumina MEG Array
Please Specify Epigenomic: 
EPIC 850K Array
Epigenomic Platform(s): 
Illumina
Please Specify Other Omics: 
Whole Exome Sequencing and Whole Genome Sequencing
Other Omics Platform(s): 
Illumina
Clinical and/or other data available?: 
Yes
Demographic information: 
Age, gender, medical history, family medical history, birth history, SES, zip code, co-morbid conditions, medications, smoking
Phenotype(s): 
blood pressure, BMI, % body fat and % body water collected every six months for 2 years (4 data points).
Data on additional variables: 
medications, psychological variables (perceived racism/discrimination, parenting stress, symptoms of depression, attitudes toward genetic testing, trauma, coping, parenting style, substance use and abuse, acculturation, ancestry
Sample Information
Samples available for prospective analysis: 
No
Whole Blood: 
No
Saliva: 
Yes
Serum: 
No
Other Tissue: 
No
Extracted DNA: 
Yes
Extracted RNA: 
No
Other Extracted Biological Material: 
No
Approximate Number of Samples: 
500
Additional Information: 
Only N=100 will have WGS completed N=500 have EWAS, GWAS, and ancestry informative markers completed N=286 have WES completed