Epigenomics of Patient Outcomes after Traumatic Brain Injury
Project Data
Contact Information
Main Point of Contact:
First Name: Yvette
Last Name: Conley
Credentials: PhD, FAAN
Institutional Affiliation: University of Pittsburgh
Email: yconley@pitt.edu
Contact Phone: 412-383-7641
Mailing Address:
University of Pittsburgh
3500 Victoria Street
440 Victoria Building
Pittsburgh, PA 15213
Study Information
Origin of Samples/Data: Human samples and/or data
Study Description: The aims of this project focus on the daily genome-wide methylomic changes that occur in DNA representing the CNS (DNA extracted from the cerebral spinal fluid (CSF) drained as standard of care) for the first 5 days after TBI using state of the science, high-throughput, genomic based methodologies; determining if this methylomic data impacts acute or long term patient outcomes after TBI.
Additional Information
Grant Number (if applicable): R21NR015142
Grant Source: NIH/NINR
Data Information
Omic Data Available: Yes
Genotype Platform(s): Illumina Human Core Exome
Please Specify Epigenomic: DNA methylation
Epigenomic Platform(s): Illumina Infinium 450K
Clinical and/or other data available?: Yes
Demographic information: age, sex, race
Phenotype(s): 3, 6, 12, and 24 month patient outcomes such as GOS, DRS, NRS, Rivermead symptom inventory; intracranial pressure; acute surgeries
Additional Information: Daily CSF samples for first 5 days after injury; daily blood samples for first 5 days after injury; daily samples linked to daily in-hospital data and longer term outcomes. In addition to availability of samples and data, my laboratory is also a resource for training in the use of these approaches.
Sample Information
Samples available for prospective analysis: Yes
Whole Blood: No
Saliva: No
Serum: No
Other Tissue: No
Extracted DNA: Yes
Extracted RNA: No
Other Extracted Biological Material: Yes
Specify Other Extracted: daily CSF, daily plasma
Approximate Number of Samples: 600
Additional Information: Daily CSF samples for first 5 days after injury; daily blood samples for first 5 days after injury; daily samples linked to daily in-hospital data and longer term outcomes. In addition to availability of samples and data, my laboratory is also a resource for training in the use of these approaches.