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Epigenomics of Patient Outcomes after Traumatic Brain Injury

Last modified: Fri, 07/31/2020 - 00:33

Epigenomics of Patient Outcomes after Traumatic Brain Injury

Project Data

Contact Information

Main Point of Contact:

First Name: Yvette

Last Name: Conley

Credentials: PhD, FAAN

Institutional Affiliation: University of Pittsburgh

Email: yconley@pitt.edu

Study Information

Origin of Samples/Data: Human samples and/or data

Study Description: The aims of this project focus on the daily genome-wide methylomic changes that occur in DNA representing the CNS (DNA extracted from the cerebral spinal fluid (CSF) drained as standard of care) for the first 5 days after TBI using state of the science, high-throughput, genomic based methodologies; determining if this methylomic data impacts acute or long term patient outcomes after TBI.

Additional Information

Grant Number (if applicable): R21NR015142

Grant Source: NIH/NINR

Data Information

Omic Data Available: Yes

Genotype Platform(s): Illumina Human Core Exome

Please Specify Epigenomic: DNA methylation

Epigenomic Platform(s): Illumina Infinium 450K

Clinical and/or other data available?: Yes

Demographic information: age, sex, race

Phenotype(s): 3, 6, 12, and 24 month patient outcomes such as GOS, DRS, NRS, Rivermead symptom inventory; intracranial pressure; acute surgeries

Additional Information: Daily CSF samples for first 5 days after injury; daily blood samples for first 5 days after injury; daily samples linked to daily in-hospital data and longer term outcomes. In addition to availability of samples and data, my laboratory is also a resource for training in the use of these approaches.

Sample Information

Samples available for prospective analysis: Yes

Whole Blood: No

Saliva: No

Serum: No

Other Tissue: No

Extracted DNA: Yes

Extracted RNA: No

Other Extracted Biological Material: Yes

Specify Other Extracted: daily CSF, daily plasma

Approximate Number of Samples: 600

Additional Information: Daily CSF samples for first 5 days after injury; daily blood samples for first 5 days after injury; daily samples linked to daily in-hospital data and longer term outcomes. In addition to availability of samples and data, my laboratory is also a resource for training in the use of these approaches.