Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure- InterGEN

Contact Information

Study Information

Origin of Samples/Data: Human samples and/or data

Study Description: Our goal is to better understand the effects of psychological, environmental, genetic, epigenetic, and ancestry factors on blood pressure in Black/African American women and their young children. We have genomic (EWAS and GWAS), psychological (perceived racism/discrimination, parenting stress, symtpoms of depression, etc) and clinical data (blood pressure, BMI, % body fat and % body water) collected at 4 times points every 6 months for 2 years on 250 African American mother-child dyads.

Additional Information

Grant Number (if applicable): R01NR013520

Grant Source: NINR

Link to Study information: https://intergen.yale.edu/

Data Information

Omic Data Available: Yes

Genotype Platform(s): Illumina MEG Array

Please Specify Epigenomic: EPIC 850K Array

Epigenomic Platform(s): Illumina

Please Specify Other Omics: Whole Exome Sequencing and Whole Genome Sequencing

Other Omics Platform(s): Illumina

Clinical and/or other data available?: Yes

Demographic information: SES, birth history, age, gender, number of children, health history, zip code, medical history, fam medical history, medications, comorbid conditions

Phenotype(s): blood pressure (hypertension), body mass index, % body fat, % body water (obesity)

Data on additional variables: medications, stress, parenting stress, trauma, coping, perceived racism/discrimination, attitudes toward genetic testing, acculturation, substance use and abuse

Additional Information: GWAS, EWAS and ancestry informative markers on N=500 Whole Genome Sequencing on N=100 samples Exome Sequencing on N=286 samples

Sample Information

Samples available for prospective analysis: No

Whole Blood: No

Saliva: Yes

Serum: No

Other Tissue: No

Extracted DNA: Yes

Extracted RNA: No

Other Extracted Biological Material: No

Approximate Number of Samples: 500