Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure- InterGEN
Project Data
Contact Information
Main Point of Contact:
First Name: Jacquelyn
Last Name: Taylor
Credentials: PhD, PNP-BC, RN, FAHA, FAAN
Institutional Affiliation: Columbia University
Email: jyt2116@cumc.columbia.edu
Contact Phone: 734-546-8115
Mailing Address:
Columbia University School of Nursing
560 W 168th Street, Room 605
New York, New York 10032
Alternative Point of Contact:
First Name: Laura
Last Name: Prescott
Credentials: MS
Institutional Affiliation: Project Manager
Email: lp2880@cumc.columbia.edu
Study Information
Origin of Samples/Data: Human samples and/or data
Study Description: Our goal is to better understand the effects of psychological, environmental, genetic, epigenetic, and ancestry factors on blood pressure in Black/African American women and their young children. We have genomic (EWAS and GWAS), psychological (perceived racism/discrimination, parenting stress, symtpoms of depression, etc) and clinical data (blood pressure, BMI, % body fat and % body water) collected at 4 times points every 6 months for 2 years on 250 African American mother-child dyads.
Additional Information
Grant Number (if applicable): R01NR013520
Grant Source: NINR
Link to Study information: https://intergen.yale.edu/
Data Information
Omic Data Available: Yes
Genotype Platform(s): Illumina MEG Array
Please Specify Epigenomic: EPIC 850K Array
Epigenomic Platform(s): Illumina
Please Specify Other Omics: Whole Exome Sequencing and Whole Genome Sequencing
Other Omics Platform(s): Illumina
Clinical and/or other data available?: Yes
Demographic information: SES, birth history, age, gender, number of children, health history, zip code, medical history, fam medical history, medications, comorbid conditions
Phenotype(s): blood pressure (hypertension), body mass index, % body fat, % body water (obesity)
Data on additional variables: medications, stress, parenting stress, trauma, coping, perceived racism/discrimination, attitudes toward genetic testing, acculturation, substance use and abuse
Additional Information: GWAS, EWAS and ancestry informative markers on N=500 Whole Genome Sequencing on N=100 samples Exome Sequencing on N=286 samples
Sample Information
Samples available for prospective analysis: No
Whole Blood: No
Saliva: Yes
Serum: No
Other Tissue: No
Extracted DNA: Yes
Extracted RNA: No
Other Extracted Biological Material: No
Approximate Number of Samples: 500