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Pain Sensitivity in Low Back Pain

Last modified: Thu, 07/23/2020 - 00:52

Pain Sensitivity in Low Back Pain

Project Data

Contact Information

Main Point of Contact:

First Name: Angela

Last Name: Starkweather

Credentials: PhD, ACNP-BC, FAAN

Institutional Affiliation: University of Connecticut School of Nursing

Email: angela.starkweather@uconn.edu

Study Information

Origin of Samples/Data: Human samples and/or data

Study Description: We conducted a prospective cohort study of 220 men and women diagnosed with an acute onset of nonspecific low back pain (LBP). We followed participants with persistent LBP and obtained measures at 6, 12, 18 and 24 weeks to evaluate changes over time. Participants who recovered at 6 weeks after the onset of LBP served as controls. The specific aims (SA) of the proposed study were to: SA1. Characterize (A) the differences in pain sensitivity between incident cases and controls at LBP onset and (B) changes in pain sensitivity over time in incident cases. H1.A Incident cases will have increased pain sensitivity compared with controls at LBP onset. H1.B Incident cases will have increased pain sensitivity over time. SA2. Compare (A) genetic polymorphisms at LBP onset between incident cases and controls and mRNA expression of candidate genes at LBP onset and at 6 weeks between incident cases and controls; and (B) differential mRNA expression of candidate genes over time in incident cases. H2.A Incident cases will have a higher frequency of polymorphisms and differential mRNA expression of candidate genes at LBP onset compared with controls. SA2.B We will examine mRNA expression levels of candidate genes over time in incident cases. SA3. Determine the contribution of enhanced pain sensitivity, cofactors (clinical/psychosocial/environmental), genetic polymorphisms, and mRNA expression of candidate genes on the risk of persistent LBP.

Additional Information

Grant Number (if applicable): R01NR013932

Grant Source: NINR

Link to Study information: https://projectreporter.nih.gov/project_info_description.cfm?aid=9125623&icde=41006083&ddparam=&ddvalue=&ddsub=&cr=1&csb=default&cs=ASC&pball=

Data Information

Omic Data Available: Yes

Genotype Platform(s): Taqman probes

Gene Expression Platform(s): RTPCR AB Step One Plus

Clinical and/or other data available?: Yes

Demographic information: Age, sex, education history, work status, history of low back pain and treatments, family history of low back pain, chronic disease history, disability

Phenotype(s): Acute pain, Chronic pain; Brief Pain Inventory Short Form; McGill Pain Questionnaire-Short Form; quantitative sensory testing

Data on additional variables: Medications, physical activity, profile of mood states, reactivity, perceived stress

Additional Information: Sample collection coincided with data collection time points

Sample Information

Samples available for prospective analysis: No

Whole Blood: Yes

Saliva: No

Serum: No

Other Tissue: No

Extracted DNA: No

Extracted RNA: No

Other Extracted Biological Material: No

Approximate Number of Samples: 500

Additional Information: Timing of sample collection corresponds to phenotype data collection