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Whole Genome Sequencing as a Screening Tool for Cardiovascular Diseases among African Americans in the Community

Last modified: Thu, 07/23/2020 - 00:52

Whole Genome Sequencing as a Screening Tool for Cardiovascular Diseases among African Americans in the Community

Project Data

Contact Information

Main Point of Contact:

First Name: Jacquelyn

Last Name: Taylor

Credentials: PhD, PNP-BC, RN, FAHA, FAAN

Institutional Affiliation: New York University

Email: jackie.taylor@nyu.edu

Alternative Point of Contact:

First Name: Laura

Last Name: Prescott

Credentials: MS

Institutional Affiliation: New York University

Email: lp83@nyu.edu

Study Information

Origin of Samples/Data: Human samples and/or data

Study Description: This project attempts to address the lack of inclusion and subsequent lack of knowledge about common and potentially pathogenic or likely pathogenic variants among African American populations and aims to provide recommendations for whole genome sequencing as a screening tool in community and clinical settings for use in early detection and treatment of cardiovascular related diseases that may help to reduce these health disparities.

Additional Information

Grant Number (if applicable): PECASE-R01NR013520

Grant Source: NINR

Data Information

Omic Data Available: Yes

Genotype Platform(s): Illumina MEG Array

Please Specify Epigenomic: EPIC 850K Array

Epigenomic Platform(s): Illumina

Please Specify Other Omics: Whole Exome Sequencing and Whole Genome Sequencing

Other Omics Platform(s): Illumina

Clinical and/or other data available?: Yes

Demographic information: Age, gender, medical history, family medical history, birth history, SES, zip code, co-morbid conditions, medications, smoking

Phenotype(s): blood pressure, BMI, % body fat and % body water collected every six months for 2 years (4 data points).

Data on additional variables: medications, psychological variables (perceived racism/discrimination, parenting stress, symptoms of depression, attitudes toward genetic testing, trauma, coping, parenting style, substance use and abuse, acculturation, ancestry

Sample Information

Samples available for prospective analysis: No

Whole Blood: No

Saliva: Yes

Serum: No

Other Tissue: No

Extracted DNA: Yes

Extracted RNA: No

Other Extracted Biological Material: No

Approximate Number of Samples: 500

Additional Information: Only N=100 will have WGS completed N=500 have EWAS, GWAS, and ancestry informative markers completed N=286 have WES completed